吸入呋塞咪对致敏豚鼠静脉注射抗原激发的抑制作用  

INHALED FUROSEMIDE EFFECT ON INTRAVENOUS ANTIGEN CHALLENGE IN OVALBUMIN SENSITIZED GUINEA PIGS

作　　者：白春学[1] 沈勋[1] 田国锋[1] 钮善福[1] 钱梓文[1] 

机构地区：[1]上海医科大学中山临床医学院肺病学教研室,上海医科大学基础医学院生理学教研室

出　　处：《上海医科大学学报》1994年第4期253-256,共4页Journal of Fudan University(Medical Science)

基　　金：卫生部基金

摘　　要：对１９只致敏豚鼠比较研究了吸入呋塞咪（９只）与不吸入呋塞咪（１０只）时静脉注射抗原激发后的呼吸力学变化。给未吸入呋塞咪的致敏豚鼠静脉注射５０μｇ卵蛋白后，肺阻力从１ｍｍ开始增加，５ｍｉｎ达高峰（超过基础值３２１％），１５ｍｉｎ回降到基础值。但给吸入呋塞咪的致敏豚鼠静脉注射同等剂量抗原后，肺阻力则无明显改变。提示吸入呋塞咪对致敏豚鼠抗原激发具有明显的抑制作用。The protective effect of inhaled furosemide against an intravenous antigen challenge was studied in ninteen ovalbumin sensitized guinea pigs.In ten sensitized guinea pigs intravenous antigen challenge without inhalation of furosemide resulted in a significant increase on pulmonary resistance(RL).RL started to increase in one minute, reached peak hills at five minutes and declined nearly to baseline in fiveteen minutes. But the same amount of intravenous antigen challenge did not cause significant RL change in nine sensitized guinea pigs after inhalation of furosemide.This indicates that inhaled furosemide has significant protective effect against intravenous antigen challenge in sensitized guinea pigs.

关 键 词：哮喘 呋塞咪 肺阻力 肺 顺应性 

分 类 号：R562.250.5[医药卫生—呼吸系统]