Χ－硒化卡拉胶与亚硒酸钠在兔的吸收与分布比较  

COMPARISON OF ABSORPTION AND DISTRIBUTION OF SELENIUM FROM -SELENOCARRAGEENAN OR SODIUM SELENITE IN RABBITS

作　　者：韩群[1] 李巧云[1] 姚凯齐 张顺国 杨香媛[1] 李端[1] 

机构地区：[1]上海医科大学药学院药理学教研室

出　　处：《上海医科大学学报》1994年第6期440-442,共3页Journal of Fudan University(Medical Science)

摘　　要：给兔灌胃Ｋａｐｐａ－硒化卡拉胶３８ｍｇ．ｋｇ＾－１和亚酸钠１ｍｇ．ｋｇ＾－１，结果显示μ－ＳｅＣ组血Ｓｅ水平的ＡＵＣ０－７２ｈ为１２．８９±３．１３ｍｇ．Ｌ＾－１．ｈ，显著高于亚硒酸钠组的８．６６±１．２０ｍｇ．Ｌ＾－１．ｈ（Ｐ＜０．０５）；μ－ＳｅＣ和亚硒酸钠组的Ｃｍａｘ分别为０．５５６±０．０８６ｍｇ．Ｌ＾－１和０．４９３±０．０９１Ｓｅｍｇ．Ｌ＾－１（ｐ＞０．０５），Ｔｍａｘ分别为４．Blood concentration and tissue distibution of in rabbits were strdied. After gastric incubation administration of kappa-selenocarrageenan( -SeC) 38mg·kg-1 and Na2SeO3 1 mg·kg-1 (both equal to 0.45 mg Se·kg-1), the AUC0-70h of -SeC group was 12. 89±3. 13 mg·L-1·h,significantly higher than 8.66±1.20 mg·L-1·h of Na2SeO3 group (P<0.05) of the two groups were 0.556±0.086 mg·L-1·h and 0.493±0.091mg·L-1(P>0.05) respectively. Tmax of -SeC group was 4. 65±1.12h and 3.47±1.07h of Na2SeO3 group(P>0.05).Se distribution of -SeC group at 24h and 72h after ig administration in five tissues (heart,liver, lung,kindey and cartilage) was significantly higher than that of Na2SeO3 group (P<0. 05 or 0. 01),Results suggest that the bioavailability of μ-SeC is greater than that of Na2SeO3.

关 键 词：硒化卡拉胶 亚硒酸钠 吸收 分布 生物利用度 

分 类 号：R965.1[医药卫生—药理学] R977.5[医药卫生—药学]