SLE患者尿中补体抑制活性的研究  

A Study on the urinary complement inhibitory activity of SLE patients

作　　者：姚建[1] 黎磊石[1] 胡伟新[1] 沈克勤[1] 

机构地区：[1]南京金陵医院

出　　处：《肾脏病与透析肾移植杂志》1994年第2期89-92,共4页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：利用改良的ＣＨ５０试验，建立了尿中补体抑制活性的检测方法，用于研究尿中补体抑制活性。结果发现活动性系统性红斑狼疮（ＳＬＥ）患者尿中补体抑制活性较正常人及非活动性ＳＬＥ患者明显增加。进一步研究发现，补体抑制活性具有部分耐受性，并与尿中红细胞计效及尿蛋白水平无平行关系。我们的研究结果首次表明ＳＬＥ患者尿中具有离水平的补体抑制活性，这一研究可能有助于加深ＳＬＥ病理生理的认识，检测尿中补体抑制活性可能具有临床诊断价值。he detecting,system for the urinary complement inhibitory activity was established by the modification of CH50 assay and used in the study of the urinary complement regulatory activity of SLE patients,A significantly increased complement inhibitory activity was found mthe urines from SLE patients as com pared with those from normal control and resting SLE,The activity was partially resistant to hcat(56℃,30min)trcatment and did not paralled with the urinary red blood cell counting and protein concentrations. This study might be helpful in deepening our understanding of pathogenesis of SLE, and the detection of urinary complement regu latory activity could have diagnostic values.

关 键 词：系统性 红斑狼疮 尿 补体 调节蛋白 

分 类 号：R593.241[医药卫生—内科学]