P物质尾核微量注射抑制小鼠胃肌电活动和胃运动  

INHIBITION OF GASTRIC MYOELECTRIC ACTIVITY AND GASTRIC MOTILITY INDUCED BY MICROINJECTION OF SUBSTANCE P INTO CAUDATE NUCLEUS IN MOUSE

作　　者：荆浩[1] 林坤伟[1] 

机构地区：[1]大连医学院生理教研室

出　　处：《生理学报》1994年第1期17-22,共6页Acta Physiologica Sinica

基　　金：国家自然科学基金

摘　　要：本文观察了小鼠尾核微量注射Ｐ物质（ＳｕｂｓｔａｎｃｅＰ；ＳＰ）或乙酰胆碱（ＡＣｈ）对胃肌电和胃运动的ｍ影响；并初步探讨了两者作用的关系。用双极康铜导线引导胃窦部肌电；用水囊连接压力换能器记录胃窦部运动。上述信息经生物电放大器和载波放大器放大后，由四道记录仪描记曲线，同时输入微机进行采集、贮存和处理。计算出注药前后每分钟胃肌电快波、慢波和胃运动波的频率和总幅度的变化百分数。结果如下：尾校注射ＳＰ或ＡＣｈ胃电快波和胃运动呈明显的抑制效应。用阿托品阻断尾核的胆碱能Ｍ受体后，ＳＰ的抑制效应基本被消除。胃电慢波的频率和幅值没有明显变化。Changes of gastric myoelectric fast wave,slow wave and gastric motility were studied after microinjection of substance P or ACh into caudate nucleus in an attempt to find the interaction between the two substances. Gastric myoelectric activity and motili ty were recorded by a RM-6200 four channel recorder and then delivered to a IBM-PC computer for analysis. After microinjection of SP or ACh into caudate nucleus, the gastric myoelectric fast wave and gastric motility were significantly suppressed, while the slow wave was not siginificantly changed.

关 键 词：胃肌电活动 胃运动 P物质 尾核 胃 

分 类 号：R333.2[医药卫生—人体生理学]