杏仁中央核注射β－内啡肽对大鼠血压和心率的影响及其机制的分析  

EFFECTS OF β-ENDORPHIN ON BLOOD PRESSURE AND HAERT RATE IN RATS

作　　者：肖强[1] 陈启盛[1] 严志红 杨睿 戴义隆 

机构地区：[1]南京医学院生理学教研室

出　　处：《生理学报》1994年第1期72-77,共6页Acta Physiologica Sinica

摘　　要：本工作采用微量注射法向大鼠杏仁中央核注射β－Ｅｎｄ，观察β－Ｅｎｄ对大鼠血压和心率的影响，并对其作用机制进行初步分析。实验结果表明：（１）β－Ｅｎｄ（１００，２５０ｐｇ／１μｌ）可引起血压降低和心率减慢，（２）纳洛酮及β－Ｅｎｄ抗血清均可拮抗β－Ｅｎｄ的效应。（３）酚妥拉明及心得安均可翻转β－Ｅｎｄ的降低血压和减慢心率的效应。结果提示：杏仁中央核注射β－Ｅｎｄ引起的心血管效应是通过阿片受体中介的，并且与肾上腺素能神经元的活动有关。The prersent work was undertake to investigate the mechanism of changes of blood pressure and heart rate induced by β-endorphin (β-End) after microinjection into the Nucleus Amygdaloideus Centralis(AC) of anaesthetized rats. The results were as follows: (1) βEnd (100, 250 pg/μl) injected into AC decreased both blood pressure and heart rate. (2) Both these effects could be antagonized by naloxone and β- End anti-serum. (3) The effects of β-End could also be reversed by phentolamine and proprenolol. The results showed that the cardiovascular effects on β-End were mediated by opioid receptors and through the intervention of adrenergic neurons.

关 键 词：杏仁中央核 血压 心率 内啡肽 

分 类 号：R338.26[医药卫生—人体生理学]