自发性高血压大鼠中枢5－HT_（1A）受体的特性  

THE CHRACTERIZATION OF 5-HT_(1A) RECEPTOR IN THE CENTRAL NERVOUS SYSTEM OF THE SPONTANEOUSLY HYPERTENSIVE RATS

作　　者：刘保坚 邱学才[1] 

机构地区：[1]北京医科大学生理教研室

出　　处：《生理学报》1994年第3期293-298,共6页Acta Physiologica Sinica

摘　　要：本文用放射性配基［３Ｈ］８－ＯＨ－ＤＰＡＴ的结合实验显示，自发性高血大鼠（ＳＨＲ）海马、下丘脑及低位脑干的５－ＨＴ１Ａ受体结合位点数较正常Ｗｉｓｔａｒ大鼠为多，其中以海马最为显著；脑干的５－ＨＴ１Ａ受体虽较正常Ｗｉｓｔａｒ大鼠多，但不太明显。ＳＨＲ下丘脑中５－ＨＴ１Ａ受体除结合位点较正常Ｗｉｓｔａｒ鼠多外，亲和力也有增大。以上结果表明，ＳＨＲ与正常Ｗｉｓｔａｒ大鼠之间各脑区中５－ＨＴ１Ａ受体的差别可能与高血压病的发生有关。With method of the radio binding assay(RBA),it was observed that in the present work that in normotensive Wistar rats, the specific binding of [3H] 8-OH-DPATat 2. 4 nmol/L concentration was about the same in hippocampus (7.62±0.24 pmol/mg), hypothalamus (8.18 ±0.63 pmol/mg) and lower brain stem (9.11±0.78pmol/mg); whereas, in spontaneously hypertensive rats(SHR),these regional specific bindings were 2+-3+times higher. Scatchard analyses showed that the Bmax was alsohigher than that of normotensive Wistar rats in hippocampus and hypothalamus, whereas the KD in hypothalamus was lower.The differences between SHR and normotensive rats in the 5-HTIA receptor contents in various brain regions appear to be related to one of the linking events in the generation of hypertension.

关 键 词：高血压 血清素 受体 

分 类 号：R544.102[医药卫生—心血管疾病]