刺激大鼠外侧缰核对脊髓背角神经元伤害性反应的影响  

EFFECTS OF LATERAL HABENULAR STIMULATION ON NOCICEPTIVE RESPONSE OF NEURONS IN RAT SPINAL DORSAL HORN

作　　者：张一红[1] 程珍凤[1] 

机构地区：[1]西安医科大学生理教研室,新乡医学院生理教研室

出　　处：《生理学报》1994年第4期320-326,共7页Acta Physiologica Sinica

基　　金：国家自然科学基金

摘　　要：电刺激大鼠一侧外侧缰核（ＬＨｂ）可对脊髓背角广动力型（ＷＤＲ）神经元的伤害性放电产生明显抑制；这种抑制效应可部分地被静脉注射赛庚啶及酚妥拉明所阻断；电解损毁ＬＨｂ对ＷＤＲ神经元的放电无影响。本文结果表明：ＬＨｂ参与了脊髓上结构对脊髓背角ＷＤＲ神经元伤害性反应的下行抑制，这种下行抑制为位相性抑制。Ipoilateral stimulation of the LHb produced a significant attenuation of nociceptive response of wide dynamic range(WDR)neurons in the rat spinal dorsal horn. The inhibitory effect produced by LHb stimulation was partially blocked by systemic cyproheptadine and phentolamine but not naloxone.No significant change was observed in the activity of WDR neurons after ipeilateral electtolytical lesions of the LHb. These results suggest that the LHb participates in the suptaspinal descending control on nociceptive respouse of WDR neurons in the spinal dorsal horn. However,tonic inhibitory mecha nism seems not to be involved.

关 键 词：下行抑制 缰核 脊髓背角 神经元 

分 类 号：R338.2[医药卫生—人体生理学]