检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:马传桃[1]
机构地区:[1]湖南医科大学心血管生理研究室
出 处:《生理学报》1994年第4期394-398,共5页Acta Physiologica Sinica
基 金:国家自然科学基金
摘 要:本实验复制清醒羊低氧性肺动脉高压模型,观察肺动脉高压发生发展及逆转过程中血浆内源性血小板活化因子(plateletactivatingfactor,PAF)的动态变化。结果表明:(1)低氧4d引起低氧血症,导致肺血管收缩,形成肺动脉高压;停止低氧后可逆转;(2)开始低氧,血中内源性PAF升高,但低氧时间延长血浆中PAF却不随肺动脉压升高相应增加;(3)停止低氧,血浆PAF不随肺动脉高压的逆转而相应降低。上述结果表明血浆PAF的变化与肺动脉高压无关。提示血中内源性PAF不介导清醒羊低氧性肺血管收缩导致的肺动脉高压。A model of hypoxic pulmonary hypertension was made in conscious sheep, and plasma platelet activating factor(PAF)were measured by radioimmuroassay method during the begining, progression and reversal of hypoxic pulmonary hypertension.The main results were as follows: (1) Under hypoxic condition for 4 days, the conscious sheep develops hypoxemia and marked hypoxic pulmonary vasoconstriction (HPV).These response were reversible. (2) At the beginning of hypoxia, plasma PAF increased, but did not continually increase with hypoxic prolongation and development of HPV. (3) Upon cessation of hypoxia with reversal of pulmonary hypertension, plasma PAF did not show any parallel decrease. These results indicate that plasma PAF is in no way involves in the development of HPV in conscious sheep.
分 类 号:R543.202[医药卫生—心血管疾病]
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.117