夏氏疟原虫入侵时小鼠红细胞膜唾液酸糖蛋白的改变  

Involvement of Membrane Sialoglycoproteins in Mice Erythrocytes Invaded by Plasmodium chabaudi

作　　者：刘俊凡[1] 卢义钦[1] 

机构地区：[1]湖南医科大学生化教研室

出　　处：《生物化学与生物物理学报》1994年第4期427-431,共5页

基　　金：美国NIH基金

摘　　要：夏氏疟原虫入侵时小鼠红细胞膜唾液酸糖蛋白的改变刘俊凡，卢义钦（湖南医科大学生化教研室，长沙４１Ｏ０７８〕ＲｏｎａｌｄＬ．ＮｏｇｅｌＯｌｇａＯ．Ｂｌｕｍｅｎｆｅｌｄ（爱因斯坦医学院内科血液学研究室和生化学系，美国纽约１０４６１）关键词夏氏疟原虫；红细胞...The extent of Participation and changes of sialoglyooproteins(SGPs)in the merozoite-mice erythrocrte interaction during the invasion of Plasmodium chabaudi were studied by immunoblotting techniques. Several bands of lower molecular weights(14.5 to 29kd) were detected in the P. chabaudi-parasitized mice erythrocytes,their saponin lysates and Pellets when cross-reacted with antihuman aGP antiserum and antipeptide C(residues 82-131) serum, implying that certain degree of structural homology exists between SGP of mice erythrocytes and aGP but not δGP of human erythrocytes. Multiple EBA-like antigens with molecular weights less than 30kd were also recognized in P. chabaudi-infected mice erythrocytes,their saponin lysates and pellets when cross-reacted with subtertian malaria hyperimmune serum.These results suggested that an intermingling of disintegrated membrane SGPs with the EBA-like antigens occurs in the mice erythrocytes invaded by P. chabaudi.

关 键 词：夏氏疟原虫 红细胞膜 唾液酸糖蛋白 

分 类 号：R382.31[医药卫生—医学寄生虫学]