PLGA－LNG微球注射剂的体内释药及载体降解的研究  

Studies on the Release Rate and Biodegradation of PLGA Microspheres Containing LNG in Vivo

作　　者：韩锦文[1] 林芳[1] 沈文照 

机构地区：[1]浙江省医学科学院

出　　处：《生殖与避孕》1994年第3期188-192,共5页Reproduction and Contraception

摘　　要：木文对高分子共聚物ＰＬＧＡ（９：１）和ＰＬＧＡ（８：２）包制的１８－甲基炔诺酮（ＬＮＧ）微球长效避孕注射剂进行了研究。结果显示二种注射剂具有比ＬＮＧ微晶释药缓慢、平稳的性能，体内生物半衰期（ｔ１／２）分别为１８．１４和１６．７２天，ＬＮＧ微晶混悬液仅为６．０１天（Ｐ＜０．０１）；抑制大鼠性周期的天数分别为４１．３０和３９．６０天，也比ＬＮＧ微晶（２４．９０天）时间长（Ｐ＜０．０１）。微球中载体ＰＬＧＡ（８：２）体内降解速度比ＰＬＧＡ（９：１）快，证实调节丙交酯（ＬＡ）与乙交酯（ＧＡ）的配比可以控制载体的降解时间。This paper describes that the release rate,the biodegradation of polymer and the estrus suppression of two kinds of polymer microspheres containing LNG in vivo.The release test in vivo was carried out in female rats by intramuscular injection of microspheres and the serum LNG levels were analyzed by RIA. The effect of estrus suppression in rats were observed with vaginal smears.The results showed that the rate of LNG releaso from microspheres was slower than that from microcrystal of LNG.With the increase of LA proportion of ALGA, the LNG release rate of microspheres decreased.The biodegradation test of polymer indicated that PLGA(8:2)degraded much faster than PLGA(9:1)The degradation rate was significantly enhanced with the inerease of glycolic acid(GA)contend in copolymers.

关 键 词：PLGA-LNG 微球 释药速率 载体降解 

分 类 号：R965.2[医药卫生—药理学]