乙型肝炎患者血清HBsAg/IgM复合物的动态观察  

Dynamic Observation of Serum HBsAg/IgM Complex in Hepatitis B

作　　者：陈世春[1] 魏宪法[1] 张国豹[2] 蔡锡麟[3] 胡筱英 

机构地区：[1]南昌市传染病院 [2]江西医学院传染病学教研组 [3]江西医学院校医学教研室

出　　处：《天津医药》1989年第1期19-22,共4页Tianjin Medical Journal

摘　　要：本文对72例乙型肝炎(乙肝)患者动态检测和观察血清 HBsAg/IgM 复合物(HBsAg/IgMc)。结果:急性和慢性乙肝患者入院初期分别有42.9%和66.7%HBsAg/IgMc 阳性。其中,85.7%的急性乙肝患者随血清转氨酶(SGPT)下降而相继 HBsAg/IgMc 阴转。慢性乙肝则表现持续阳性(P<0.01)。经相关分析发现,急性乙肝 HBsAg/IgMc 阳性多伴有高滴度的抗-HBcIgM,并随后者滴度下降而转阴;早期 HBsAg/IgMc 阴转者 HBeAg 多可消失,并相继抗-HBe 阳转,预后良好。表明该复合物是急性 HBV 感染的早期血清学指标之一,并对预后的顶测和急慢性 HBV 感染的鉴别具有临床参考价值。The serum HBsAg/IgM complexes(HBsAg/IgMc)was determined and observatedin 72 cases of hepatitis B.The results showed that serum HBsAg/IgMc positive wasrespectively present in 42.9% and 66.7% of patients with acute or chronic hepatitisB.However,after the HBsAg/IgMc turned negative,the serum amino-transaminase(SGPT)level of patients with acute hepatitis B decreased,but not in those withchronic hepatitis B(P<0.01).In the correlative analysis patients with acute hepatitiswhich had positive for serum HBsAg/IgMc mostly were associated with high titerwith serum anti-HBcIgM.When the HBsAg/IgMc negative occured at the early stageof the illness the serum HBeAg decreased,and anti-HBe developed with good prog-nosis.It was suggested that the complexes were an early serologic index in acuteHBV infection,and to helpful for both the prognosis and differentiation betweenacute or chronic HBV infections.

关 键 词：乙型肝炎 表面抗原 免疫球蛋白G 

分 类 号：R512.62[医药卫生—内科学]