通过血浆中前列环素和血栓素的变化评价妊娠高血压综合征的疗效  

Evaluation of Therapeutic Results of Pregnancy Hypertension Syndrome by Changes in Plasma Prostacyclin and Thromboxane

作　　者：王淑雯[1] 刘润环[1] 姚天一[1] 胡云霞[1] 王懿贤[2] 

机构地区：[1]天津市中心妇产科医院产科 [2]天津市中心妇产科医院实验室

出　　处：《天津医药》1989年第1期3-7,共5页Tianjin Medical Journal

摘　　要：本文报导了30例“妊高征”患者的血浆中前列环素(PGI_2)和血栓素 A_2(TXA_2)的变化,分别采取中医、西医、中西医结合治疗。应用放免测定 PGI_2和 TXA_2的较稳定的代谢产物6-Keto-PGF_1α与 TXB_2的数值及其比值,提出“妊高征”患者血中 PGI_2和 TXA_2平衡失调。对中医、西医、中西医结合治疗的三组病人分别于治疗前、后取血,测血浆中6-Keto-PGF_1α、TXB_2及 T/P 比值。观察三组治疗效果,根据治疗前、后的临床症状,临床化验、母婴情况及 TXB_2及6-Keto-PGF_1α及两者比值的改变判定疗效。三组中以中西医结合治疗效果较为理想。并认识到研究 PG 类代谢与“妊高征”的发生发展的关系,有助于对“妊高征”发病机制的阐明和病变严重程度的估计。对探讨特异性抑制 TXA_2合成酶的药物,减少 TXB_2的合成,寻找刺激 PGI_2合成和抗血小板凝聚的药物,为防治“妊高征”开辟新的途径有着重要意义。Thirty pregnant hypertensin syndrome cases divided into three groups were trea-ted with methods of traditional chinese medicine,western medicine and combinedmedicine respectively.Radioimmunologic assay of TXB_2 and 6-Keto-PGF_1a,the relatively stable metabo- lites of TXA_2 and PGI_2 was carried on and their ratio taken.The changes of PFI_2and TXA_2 in serum were carefully analysed and the imbalance of PGI_2 and TXA_2was comfirmed in pregnant women with hypertension.Blood was taken from three groups ante-and post-treatment respectively andvalues of 6-Keto-PCF_1a and TXB_2 were measured and their T/P ratio was taken.Thetherapeutic effect of the three groups was observed and determined according toclinical symptoms before and after treatment,laboratory examinations,maternal andinfantile conditions,values of TXB_2 and 6-Keto-PGF_1a and the changes of theirratio as well.Among the three groups the therapeutic effect of combined medicinewas the best.Studies on the relationship between PG metabolism and occurrance and develop-ment of pregnant hypertension syndrome were helpful for explanation of pathologi-cal machanism of this syndrome and assessment of the severity and for the approachof specific medicine for restricting TXA_2 enzyme synthesis,decressing TXB_2synthesis,stimulating PGI_2 synthesis and anti-platelet aggregation.It was consideredof great significance for the prophylaxis and treatment of pregnant hypertensionsyndrome.

关 键 词：高血压 血浆 前列环素 血栓素 妊娠 

分 类 号：R714.253[医药卫生—妇产科学]