心钠素对脱水大鼠脑[^(14)C]-脱氧葡萄糖摄取的影响  

Effect of Atrial Natriuretic Peptide on [^(14)C]-2-Deoxyglucose Uptake in Brain of Dehydrated Rats

作　　者：马丽云[1] 张墨玲[1] 郗树清 张殿明[1] 田德润[1] 张欣[1] 吕梦翔[1] 

机构地区：[1]天津医学院天津市内分泌研究所

出　　处：《天津医药》1989年第12期733-735,共3页Tianjin Medical Journal

基　　金：国家自然科学基金

摘　　要：以[^(14)C]-脱氧葡萄糖放射自显影方法,观察了在脱水状态下大鼠脑室内注射人工合成的心钠素Ⅲ后,脑内含有加压素神经元核团的脱氧葡萄糖摄取的视密度值,与对照组相比,均明显低下。穹窿下器官的视密度值下降为18%,下丘脑室旁核下降为12.3%,视上核为13.8%,视交叉上核为15.5%,经统计学处理均有显著性差异。结果表明,脑内脱氧葡萄糖摄取降低可能是由于脑室内注入心钠素Ⅲ可以抑制由于脱水而引起的葡萄糖代谢增强的作用。The local ratio of optical density of glucose uptake,by means of autoradiographic〔~14C〕-2-deoxyglucose method,in cerebral regions involved in the vasopressin containingstructures was reported.The water-deprived rats were treated either with AP~Ⅲ(by ICV injection)or saline.The optical density of autoradiographs in each brainstructure was determined directly by a Digital Densitometer.It was found that theglucose uptake was significantly reduced in subfornical organ(18%),paraventricularnucleus(12.3%),supraoptic nucleus(13.8%)and suprachiasmatic nucleus(15.5%)inAP~Ⅲ treated group as compared with those in the control group.The results indicatedthat the decreased glucose uptake in bra(?)n regions might be due to the inhibitingeffect of AP~Ⅲ on increased vasopressin induced by dehydration in the hypothalamusand circumventricular.

关 键 词：心纳素 脱氧葡萄糖 鼠 脑 碳14 

分 类 号：R972.4[医药卫生—药品]