八肽胆囊收缩素抗血清翻转针刺耐受的电生理学研究  

ELECTROPHYSIOLOGY STUDY ON REVERSAL OF ACUPUNCTURE TOLERANCE BY ANTISERUM AGAINST CHOLECYSTOKININ OCTAPEPTIDE

作　　者：边景檀[1] 孙明智 韩济生 

机构地区：[1]天津师大,哈医大,北医大

出　　处：《天津师大学报（自然科学版）》1994年第1期52-56,共5页

摘　　要：动物整体水平研究证实，八肽胆囊收缩素抗血清（ＣＣＫ－ＡＳ）可翻转电针耐受，而ＣＣＫ－ＡＳ本身不影响基础痛阈。本文采用记录神经元放电的方法证明：脑室注射ＣＣＫ－ＡＳ能翻转对长时间电针产生耐受效应的大鼠丘脑束旁核痛兴奋神经元（ＰＥＮ）和痛抑制神经元（ＰＩＮ）的电活动，使电针镇痛效应重新出现。而脑室注射正常兔血清（ＮＲＳ）对产生电针耐受效应的ＰＥＮ和ＰＩＮ的电活动无影响。从细胞水平得到的这一结果与整体水平研究的证据相一致。提示，内源性ＣＣＫ－８参与电针耐受可能是电针镇痛受到拮抗的机制之一。这一发现同时为临床医学实践提供了进一步的依据。In this paper, by recording neuronal discharges and an antibody microinfection technique, we demonstrate that electric activity of pain excited neurons(PEN) and pain inhibited neurons (PIN) in the nucleus parafascicularis of rat thalamus displaying electroacupuncture tolerance(EAT) effect can be reversed by antiserum against CCK-8(CCK-AS) administered intracerebroventricularly (i.c.v.), electroacupuncture(EA) analgesia can reappear. As control, the i.c.v. injection of normal rabbit serum(NRS) can not reverse the activity of PEN and PIN producing EAT effect. All above suggests that endogenous CCK-8 involved in EAT may be one of the main mechanisms of EA analgesia antagonised.

关 键 词：八肽胆囊 收缩素 针灸学 电针耐受 

分 类 号：R245[医药卫生—针灸推拿学]