尿毒症患者淋巴细胞产生IL-2能力及IL-2R表达的初步探讨  

Studies on lnterleukin-2 Production and lnterleukin-2 Receptor Expression in Chronic Uremic Patients

作　　者：于文慧[1] 马腾骧[1] 张璐仁[1] 陈璋[2] 杨希峰[2] 

机构地区：[1]天津医学院第二附属医院 [2]中国医学科学院血液学研究所

出　　处：《天津医药》1994年第1期3-5,共3页Tianjin Medical Journal

摘　　要：测定35例尿毒症患者淋巴细胞产生白细胞介素-2(IL-2)的活性水平和淋巴细胞白细胞介素-2受体(IL-2R)的表达。与正常对照组比较发现,透析和未透析尿毒症患者的淋巴细胞产生IL-2的活性水平均明显下降,激活前淋巴细胞IL-2R表达增多。尿毒症患者经慢性维持性血液透析后,淋巴细胞产生IL-2的活性水平有一定提高。研究结果为改善尿毒症患者的细胞免疫功能提供了实验依据。The production of interleukin -2 (IL-2) and interleukin-2 receptor (IL-2R) expression by peripheral blood mononuclear cells(PBMC) in 35 patients with uremia were investigated. The results showed; The production of IL-2 was markedly lower in chronic hemodialyzed (CHD) and non-hemodialyzed (NHD) uremic patients than that in normal group. CHD and NHD patients had a significantly higher expression of IL-2R on the surface of PBMC before PHA stimulation. The production of IL-2 in CHD uremic patients is higher than that in NHD uremic patients. Thus, the decrease of IL-2 production may be a cause of impaired cell-mediated immunity in uremia.

关 键 词：尿毒症 血液透析 白细胞介素2 

分 类 号：R692.5[医药卫生—泌尿科学]