肺心病患者血LPO、GSH、SeGSH-Px水平及动态观察  

Dynamical Observation of Levels of LPO, GSH, SeGSH Px in Blood in Patients with Chronic Cor Pulmonale

作　　者：王予思[1] 秦朝辉[1] 盖俊惠 高庆珍[1] 

机构地区：[1]山西医学院第一附属医院内科,030001

出　　处：《天津医药》1994年第3期137-139,共3页Tianjin Medical Journal

摘　　要：测定肺心病患者急性发作期血中LPO、GSH含量升高,SeGSH-Px含量降低,与正常组对照差异显著。对27例肺心病患者的血LPO、GSH、SeGSH-Px进行动态观察,结果表明急性期血LPO含量明显高于缓解期,缓解期血SeGSH-Px含量明显高于急性期,提示可用这三项指标监测肺心病病情转化。回归方程提示肺心病患者血LPO、GSH、SeGSH-Px含量与肺心病分期、血pH和Hb含量有高度相关性。In our study, levels of LPO and GSH were higher in blood in patients with cor pulmonale, inverse SeGSH-Px was lower than those of control group. Dynamical observation of 27 cases with cor pulmonale showed that the level of LPO was obviously higher in acute phase than in relax phase, and the level of SeGSH-Px was significantly lower in relax phase than in acute phase. These levels may be used to moni-ter the clinical changes of cor pulmonale. Analysis of multiple stepwise regression showed that there were high correlations between the levels of LPO, GSH, SeGSH-Px and the various phase, pH value, hemoglobin content.

关 键 词：肺心病 谷胱甘肽 过氧化脂质 

分 类 号：R541.5[医药卫生—心血管疾病]