非胰岛素依赖型糖尿病早期肾病变  

Diabetic Nephropathy in Recent Cases of Non-insulin Dependent Diabetes Mellitus

作　　者：叶蓉绍[1] 奚淑静[2] 盛正妍[1] 

机构地区：[1]上海市第一人民医院内分泌科,200080 [2]上海市第一人民医院中心实验室,200080

出　　处：《天津医药》1994年第5期285-287,共3页Tianjin Medical Journal

摘　　要：观察5年内发病的NIDDM病人48例。检测尿微白蛋白(MAU)、白蛋白排泄率(AER)、血清β_2-mG、Ccr、24小时尿蛋白等。AER阳性率明显高于血清β_2-mG、Ccr、24小时尿蛋白的阳性检出(P<0.01)。AER与血清β_2-mG及Ccr呈显著相关(P<0.01)。AER是诊断糖尿病早期肾素的可靠依据。于NIDDM肾病变诸多影响因素中高血压是至关重要的。高血压与肾病相互影响,故抗高血压治疗可改善和延缓肾病变的发展。Microalbuminuria (MAU), rate of albumin excretion (AER), serum microglobu-lin (S-β2mG), creatinine clearance (Ccr) and 24h urine protein were observed in 48 patients with non-insulin dependent diabetes mellitus of onset in recent 5 years. The rate of MAU and AER in incipient diabetic nephropathy was significantly higher than that of S-β2mG and Ccr (P<0.01). AER correlated significantly with S-β2mG and Ccr (P<0.01). AER was a reliable index in diagnosing incipient diabetic nephropathy. The most important influencing factor of non-insulin dependent diabetic nephropathy was hypertension. Hypertension and nephropathy are effected each other, therefore, antihypertension therapy may improve and delay the development of diabetic nephropathy.

关 键 词：尿 白蛋白 排泄率 糖尿病肾病 

分 类 号：R587.106[医药卫生—内分泌]