自身免疫甲状腺疾病患者淋巴细胞亚群和自身抗体的检测及其临床意义  

Assay and Clinical Significance on Lymphocyte Subpopulation and Autoantibodies in Patients with Autoimmune Thyroid Diseases

作　　者：钟述猷[1] 董晖[1] 张宝泉[2] 王淑芬[3] 阮大宝[3] 方佩华[4] 

机构地区：[1]天津医学院附属医院免疫实验中心,300052 [2]天津医学院附属医院核医学科,300052 [3]天津医学院附属医院儿科,300052 [4]天津市内分泌研究所

出　　处：《天津医药》1994年第7期391-394,共4页Tianjin Medical Journal

摘　　要：报告150倒自身免疫甲状腺疾病和25例亚急性甲状腺炎患者淋巴细胞亚群和甲状腺自身抗体测定结果。GD和HT未治组CD_8^+下降,CD_4^+/CD_8^+比值和CD_(20)^+升高(均P<0.01)。自身抗体TRAb、TMA和TGA阳性率GD未治组分别为88.9％,66.1％、57.8％,HT未治组为20.0％、76.7％、70.0％。亚甲炎组以上各指标变化不明显。GD缓解组相应各指标转向正常范围。GD未治组CD_8^+与TAAb呈明显负相关,CD_(20)^+与TRAb呈明显正相关。实验表明CD_8^+、CD_(20)^+与TRAb的检测是判断Graves病及其治疗效果和预后的可靠指标。Lymphocyte subpopulations and autoantibodies were investigated in 150 patients with autoimmune thyroid diseases and 25 patients with subacute thyroiditis. In the untreated group of Graves' disease (GD) and Hashimoto thyroiditis (HT) CD3+ and CD8+ were markedly declined while the ratio of CD4+CD8+ and CD20+ were significantly elevated (P<0.01>. In the untreated group of GD, the positive rate for TRAb, TMA and TGA were 88.9%, 66.1% and 57-8% respectively, while they were 20.0%, 76.7% and 70.0% in the untreated group of HT. There was no significant change found in the subacute thyroiditis. In the remitted group of GD, these indices were turned to the normal limits. It was noted in the untreated GD group that there wasa stronger negative correlation between TRAb and CD8+ than the positive correlation between TRAb and CD20+. The data suggest that CD8+, CD20+ and TRAb might be the reliable indices for the judgement of the treatment and prognosis of Graves' disease.

关 键 词：甲状腺炎 甲状腺 抗体 甲亢 

分 类 号：R581.1[医药卫生—内分泌]