放射免疫显象时肠道放射性来源机理的实验研究  

Experimental Study on Mechanism of theSource of Bowel Radioactivity During Ra-dioimmunodetection

作　　者：吴复平[1] 刘璐[1] 伍福庆[1] 

机构地区：[1]南京铁道医学院附院核医学科,南京铁道医学院附院放射科

出　　处：《铁道医学》1994年第6期321-323,共3页Railway Medical Journal

摘　　要：放射免疫显象时的肠道放射性常导致腹部显像结果判断的困难。为了研究肠道放射性来源机理，将大鼠分为胆总管切断组和对照组，在注射１１１铟标记的ＺＭＥ－０ｌ８（抗黑色素瘤，ＩｇＧ２ａ）后，肠道放射性在两组间无显著性差异。说明单克隆抗体ＺＭＥ－０ｌ８直接被肠壁吸收而不通过胆道排泄；在注射１１１铟标记的ＺＣＥ－０２５后，胆总管切断组肠道放射性较对照组低３０％，说明单克隆抗体ＺＣＥ－０２５（抗癌胚抗原，Ｉｇ１）既被肠壁直接吸收，又通过胆道排泄。owel radioactivity may be seen followingthe administration of some 111 In or 99m TcMcAbs and consequently interfere with the in-terpretation of abdominal imagcs. In order toinvestigate the mechanism by which McAbsenter the gut, groups of rats underwent bileduet ligation while others served as sham op-erated controls. Following i. v. injection of 111In ZME - 018 (IgG 2a. anti - melanomaMcAb), there was no significant differencebetween the corzibined intestinal wall and fecaliadioactivity in the control rats and the bileduet .ligated group, suggesting that this McAbwas transported directly across the bowelwall. Following i. v. injection of 111 In ZCE-025 (IgG1, anti - carcinoembryonic antigenMcAb), there was a 30% decrease in gut ra-dioactivityin the bile duct ligated rats com-pared to the control group, suggesting thatboth direct transport across the bowel walland hepatobiliary excretion contributed tobowel radioactivity

关 键 词：放射性核素显像 单克隆抗体 铟 碘 消化道 

分 类 号：R817－33[医药卫生—影像医学与核医学]