大孔吸附树脂纯化注射用栀子提取物的研究  

Studies on purification of the extract of fructus gardeniae for injection by macroreticular resins

作　　者：陈钢[1] 侯世祥[1] 叶利民[1] 胡平[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《中国中药杂志》2005年第3期188-190,共3页China Journal of Chinese Materia Medica

摘　　要：目的初步探讨大孔吸附树脂应用于中药注射剂纯化的特点和评价方法。方法以栀子提取液为样本,使用大孔吸附树脂纯化得到其提取物,并从提取物的粉体学特性、有效成分定性定量分析、安全性、稳定性等方面来评价其质量和纯化方法的合理性。结果采用大孔吸附树脂成功制得符合注射用要求的栀子提取物。结论大孔吸附树脂技术可用作中药注射剂的纯化工艺,但需建立完善的质量评价方法以确保制剂的安全、有效、稳定。Objective: To purify of the extract of fructus gardeniae for injection by macroreticular resins in purification process of traditional Chinese medicine(TCM) Injections. Method: Using fructus gardeniae as sample, on base of obtaining the extract by employing macroreticular resin, quality evaluation and rationality of purification methods had been studied by the quantitive analysis of active ingredients and the characteristics of micromeritics, safety and stability of the extract. Result: The experiment showed the extract of fructus gardeniae for injection had been produced successfully by macroreticular resin. Conclusion:Using macroreticular resins is a promising purification way of TCM injections, whereas a more consummate method of quality evaluation must be established to ensure safety, efficiency and stability of the preparation in the process. [

关 键 词：大孔吸附树脂 注射用 提取物 栀子 中药注射剂 纯化工艺 制剂 粉体 纯化方法 研究 

分 类 号：R283[医药卫生—中药学]