羟基磷灰石涂层的生物仿生法研究进展  

Advance in Biomimetic Deposition Hydroxyapatite Coating

作　　者：林岚云[1] 刘榕芳[1] 肖秀峰[1] 

机构地区：[1]福建师范大学化学与材料学院,福州350007

出　　处：《硅酸盐通报》2005年第1期70-75,共6页Bulletin of the Chinese Ceramic Society

基　　金：福建省自然科学基金重大项目资助(2000F003)

摘　　要：羟基磷灰石的生物复合涂层具有很高的外科应用价值。制备羟基磷灰石复合材料的方法有很多种,其中仿生法模仿了自然界生理磷灰石的矿化机制,在类似于人体组织内环境条件的水溶液中自然沉积出磷灰石层。仿生法具有许多其它方法无可比拟的优越性。本文对近年来文献报道中出现的生物仿生法进行了综述,阐述了各种仿生法中包括对基体进行预处理使其表面官能团化,再将基体在模拟体液中浸泡从而使磷灰石自然沉积的模拟生物矿化的4个阶段的工艺过程及其仿生机理。Biomimetic deposition hydroxyapatite coatings have high value on clinical application. There are many methods to fabricate hydroxyapatite composite materials. Among them, the biomimetic methode mimics the mineralization of natural physiological apatite, and the apatite coatings are precipitated from the aqueous solution with condition nearly equal to those of human tissue environment in vivo. So the biomimetic method offers the most promising advantages than other coating methods. In this paper, the research status of biomimetic method of hydroxyapatite is reviewed, the technological process which mimic the four steps of biomineralization is elaborated,including that the substrates are pretreated for their surface functionalization and soaked into the simulated body fluid (SBF) accelerating the formation of apatite,and the biomimetic mechanism.

关 键 词：仿生法 羟基磷灰石涂层 外科应用 研究进展 内环境 人体组织 模拟体液 表面官能团 基体 工艺过程 

分 类 号：TQ174[化学工程—陶瓷工业] R318.08[化学工程—硅酸盐工业]