两种^(99)Tc^m标记双功能螯合剂:NHS-MAG3和HYNIC  

Two bifunctional chelating agents used in ^(99)Tc^m labeling:NHS-MAG3 and HYNIC

作　　者：兰晓莉[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院核医学科,武汉430022

出　　处：《国外医学（放射医学核医学分册）》2005年第1期15-18,共4页Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)

基　　金：国家自然科学基金项目(30271439);高等学校博士点基金项目(20030487013)

摘　　要：99Tcm在标记蛋白、核酸、多肽和抗体时,常采用双功能螯合剂作为偶联剂的间接标记法,以避免直接标记所带来的损伤。研究表明,近年来常用的两种螯合剂NHS-MAG3及HYNIC合成路线清晰,偶联及标记方法成熟,标记率、放化纯及比活度较高,为核素分子显像提供了必要的基础条件和广阔的临床应用前景。When protein, nucleic acid, polypeptide and antibody labeled with 99Tcm, bifunctional chelating agents(BFCA)are commonly used in order to avoid damages by directly labeling. We choose two BFCA:NHS-MAG3 and HYNIC as representation. The synthesis of these two BFCA is clear and the meth-ods of conjugating and labeling are mature. Through BFCA we can gain high radiolabeling yield, radiochemi-cal purity and specific activity. The usage of BFCA can provide necessary condition for molecular imaging and extensively clinical foreground.

关 键 词：双功能螯合剂 巯基乙酰三甘氨酰-N-羟基丁二酰亚胺酯 肼基尼古酰胺 锝 同位素标记 

分 类 号：R817[医药卫生—影像医学与核医学]