联合采用降压药物治疗原发性高血压病的临床意义  

The Clinical Significance of Combined Drug Therapy in Essential Hypertension

作　　者：曹悦鞍[1] 龙南展[1] 彭朝胜[1] 毛丽华[1] 王玮[1] 夏菁[1] 臧贵明[1] 

机构地区：[1]北京海军总医院干三科,北京100037

出　　处：《中国临床医学》2005年第1期17-18,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:探讨单剂与联合应用降压药物对高血压患者血压的影响及临床意义。方法:选取正在口服抗高血压药物至少1 个月以上的高血压病患者380例,按服用单剂(EH1组,212例)和联合用药(EH2组,168例)进行分组,对比分析血压控制情况及降压有效率。单独分析31例高血压合并糖尿病患者的血压控制情况。结果:EH2组的降压有效率(83.9%)明显高于EH1组(56.6%,P<0.005);EH2组的平均收缩压与舒张压均低于EH1组(P<0.001);服用单剂降压药物无效而改为增加药物剂量的患者,其血压降低均值明显小于改为联合用药的患者(P<0.01);31例高血压病合并糖尿病的患者降压有效率仅为35.5%,并且多为联合用药的患者。结论:小剂量联合应用抗高血压药物的降压效果明显优于单剂药物,单剂药物效果不明显而改为联合用药的降压效果明显优于单剂药物增加剂量的效果。Objective: To evaluate the clinical significance of combined drug therapy in essential hypertension. Methods: 380 essential hypertensive patients who had taken oral antihypertensive drug at least one month were divided into two groups. 212 patients with the single drug therapy (EH1) and 168 patients with the combined drug therapy (EH2). Blood pressure changes and antihypertensive efficacy were studied. Results:the effective ratio in EH2group(83. 9%) was higher significantly than that in EH1 group (56. 6%).p<0. 005. And, the average SBP and DBP in EH2 were significantly lower than EH1 ,p<0. 001. The magnitudes of reduction of BP in the patients who need to increase dosage in EH1 were also apparently lower than the patients who changed to combined drug therapy. The efficacy of decrease BP in 31 hypertensive patients with type 2 diabetes mellitus were only 35. 5%. And most of them took combined drug therapy. Conclusion: Lower dosage combined drug therapy in hypertension can significantly increases the efficacy of the antihypertensive agent than sigle drug therapy.

关 键 词：EH 降压药物 患者 联合用药 治疗 单剂 有效率 增加 合并 平均 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]