肿瘤标记物在原发性肾脏疾病患者中的血清学浓度改变  

Serum Levels of Four Tumour Markers in Primary Kidney Disease Patients

作　　者：张悦[1] 叶志斌[1] 吉俊[1] 

机构地区：[1]复旦大学附属中山医院肾病科,上海200032

出　　处：《中国临床医学》2005年第1期135-137,共3页Chinese Journal of Clinical Medicine

摘　　要：目的:了解24 h尿蛋白定量、血浆白蛋白、肌酐清除率(Ccr)水平对原发性慢性肾脏病患者血清甲胎蛋白(AFP)、癌胚抗原(CEA)、糖蛋白抗原19-9(CA19-9)和糖蛋白抗原125(CA-125)血清浓度的影响。方法:测定92例非透析慢性肾脏病患者上述4种肿瘤标记物血清浓度,根据其Ccr、24 h尿蛋白定量以及血浆白蛋白浓度进行分组,并对数据进行统计学分析。结果:24 h尿蛋白定量和血浆白蛋白浓度对血清CA125水平有显著影响,尿蛋白定量增加及血浆白蛋白浓度降低者血清CA125 均值升高。不同蛋白尿或Ccr组以上其他3种肿瘤标记物的血浓度无明显差异。结论:尿蛋白定量增加和血浆白蛋白降低的慢性肾病患者,其血浆CA125浓度升高时并不一定提示恶性肿瘤,Ccr、24 h尿蛋白定量、血浆白蛋白水平对AFP、CEA、CA19-9无明显影响。Objective:To assess the clinical value of four tumour markers (AFP, CEA, CA125, CA19-9) in primary kidney disease patients with protenuria or chronic renal failure. Methods: Ninety-two randomizedly selected hospitalized patients with primary kidney diseases were divided into several groups according to the levels of Ccr,24 h protenuria and serum albumin. The four markers between different groups were compared. Results:CA 125 levels and 24 h urinary protein excretion were elevated in the patients with hypoalbuminuria as well as compared to the normal controls. Serum CEA, AFP and CA19-9 levels were within normal limits in all of the groups. Conclusion: Elevated serum CA125 level seems to be unreliable for monitoring malignancies in patients with hypoalbuminuria or heavy protenuria ,There were no correlations between serum levels of CEA, AFP or CA19-9 and Ccr 24 h urinary protein and plasm albumin level.

关 键 词：尿蛋白定量 血浆白蛋白 患者 肿瘤标记物 原发性 慢性肾脏病 血清CA125 增加 影响 降低 

分 类 号：R692[医药卫生—泌尿科学] R737[医药卫生—外科学]