中西医结合治疗妊娠期肝内胆汁淤积症疗效观察  

Observation on therapeutic effect of traditional Chinese and western medicine used in intrahepatic cholestasis of pregnancy

作　　者：张海鹰[1] 郭晓辉[1] 

机构地区：[1]暨南大学医学院第二附属医院,518020

出　　处：《中国妇幼保健》2005年第5期553-555,共3页Maternal and Child Health Care of China

摘　　要：目的:评估中西医结合治疗妊娠期肝内胆汁淤积症(ICP)的临床疗效.方法:对2002年1月～2004年5月收治的42例ICP患者随机分成两组,对照组20例采用一般治疗,观察组22例在一般治疗的基础上加用:①ICP中药方,每日1剂,10日为1疗程;②地塞米松6 mg,肌肉注射,2次/d,共2d,观察治疗效果及围产儿结局.结果:观察组总有效率为86.4%,明显高于对照组10.0%,P＜0.01.观察组治疗后血总胆汁酸(TBA)、丙氨酸转氨酶(ALT)明显下降,P＜0.01,而对照组无明显变化.观察组较对照组孕周延长,剖宫产率降低,围产儿结局良好(P＜0.05).结论:中西医结合治疗ICP安全、有效,能明显改善围产儿结局.Objective:To evaluate the clinical therapeutic effects of traditional Chinese and western medicine on intrahepatic cholestasis of pregnancy (ICP).Methods:42 patients with ICP from January 2002 to May 2004 were randomly divided into two groups, 20 patients in control group received common treatment, 22 patients in observing group were treated on the basis of general treatment, with traditional Chinese medicine for ICP (one dose, taken orally daily for 10 days); dexamethasone (6 mg, injected intramuscularly, 2 times daily for 2 days), the efficacy and perinatal outcome were compared between two groups.Results:The total effective rate in observing group was obviously higher than that in control group (86.4% vs 10.0%, P<0.01).After treatment serum total bile acids (TBA) and alanine aminotransferase (ALT) decreased significantly in observing group (P<0.01), whereas there were no significant changes in control group (P<0.05).In observing group, the cesarean section rate decreased, the gestational weeks increased and perinatal outcome was improved (P<0.05).Conclusion:Traditional Chinese and western medicine may be an effective and safe method for ICP, which could improve perinatal outcome.

关 键 词：肝内 胆汁淤积 中西医结合 妊娠结局 

分 类 号：R714.255[医药卫生—妇产科学]