益母草水提液对兔胸主动脉条收缩反应的影响  

Effect of Water Extract from Herba Leonuri on Contraction of Rabbit Aorta Smooth Muscle

作　　者：关利新[1] 衣欣[2] 冯芹喜[1] 杨履艳[1] 

机构地区：[1]黑龙江省牡丹江医学院药理教研室,157011 [2]黑龙江省牡丹江医学院临床药理教研室,157011

出　　处：《医药导报》2005年第3期176-177,共2页Herald of Medicine

摘　　要：目的研究益母草水提液(WELLS)对血管平滑肌收缩反应的影响。方法以体外兔胸主动脉条为标本,观察不同浓度WELLS对去甲肾上腺素(NE)、氯化钾(KCl)和氯化钙(CaCl2)量效曲线的影响。结果对于NE,25mg·mL1WELLS为激动剂,可使NE最大反应增加(6±4)%,50和75mg·mL1WELLS为部分激动剂;对于KCl,25mg·mL1WELLS为部分激动剂;对于CaCl2,50mg·mL1WELL为部分激动剂。结论WELLS对血管平滑肌的收缩反应与浓度有关,高浓度时可能主要阻滞电压依赖性钙通道,而低浓度时可能主要激动受体调控性钙通道。Objective To study the effect of water extract from herba leonuri on the contraction of rabbit aorta smooth muscle. Methods The influences of water extract from herba leonuri on the dose-effect curve of norepinephrine (NE), potassium chloride (KCl) and calcium chloride (CaCl_~2 ) were observed on the isolated aortic strips of rabbits. Results To the dose-effect curve of NE, 25 mg·mL^-1 water extract from herba leonuri worked as a agonist and the highest response increased was (6±4)%, 50 mg·mL^-1 and 75 mg·mL^-1 of the extrat worked as partial agonists. To the dose-effect curve of KCl and of CaCl_~2 , 25 mg·mL^-1 and 50 mg·mL^-1 of the extract worked as partial agonists, respectively. Conclusion The contraction on the vascular smooth muscle by water extract from herba leonuri were related to the concentration of the extract, the higher concentration might mainly block potential-dependent calcium channel and the lower concentration might mainly block receptor-operating calcium channel.

关 键 词：益母草水提液 胸主动脉 去甲肾上腺素 氯化钾 

分 类 号：R282.71[医药卫生—中药学] R285.5[医药卫生—中医学]