哌拉西林舒巴坦与哌拉西林他唑巴坦随机单盲对照治疗细菌感染  

A randomized single-blind controlled trial of piperacillin/sulbactam and piperacillin/tazobactam in treatment of bacterial infections

作　　者：蔡素芳[1] 余泽波[1] 段明纲[1] 郑行萍[1] 

机构地区：[1]重庆医科大学附属第一医院感染科,重庆400016

出　　处：《中国新药与临床杂志》2005年第3期203-206,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的:评价哌拉西林-舒巴坦治疗细菌感染的有效性和安全性.方法:入选病例77例,其中试验组38例[男性9例,女性29例,年龄(38±s 16)a],临床疗效评价37例,安全性评价38例;对照组39例[男性16例,女性23例,年龄(38±16)a],临床疗效评价38例,安全性评价39例.采用随机单盲对照试验方法.试验组和对照组分别用哌拉西林-舒巴坦每日剂量10～20 g,哌拉西林-他唑巴坦每日剂量9～18 g,分3次溶于100mL 5%葡萄糖或氯化钠注射液中静脉滴注,疗程均5～14 d.结果:试验组和对照组总临床有效率均为97%,总细菌学有效率分别为96%和100%,药敏试验显示对致病菌的敏感率分别为98%和100%,不良反应发生率均为5%.结论:哌拉西林-舒巴坦对敏感菌引起的细菌感染疗效确切,安全性好.AIM: To evaluate the efficacy and safety of piperacillin/sulbactam in the treatment of bacterial infections. METHODS: Seventy-seven patients with bacterial infections were selected in this study including 38 patients enrolled in piperacillin/sulbactam group(M 9,F 29;age(38±s 16) a) with 37 patients assessed for efficacy and all of the members for safety; and other 39 patients enrolled in piperacillin/tazobactam group(M 16, F 23;age (38±16) a) with 38 of them assessed for efficacy and totally for safety. Under the conduction of a randomized single-blind control trial, the daily dosages were 10-20 g for piperacillin/sulbactam and 9-18 g for piperacillin/tazobactam 5 % glucose or 0.9 % sodium chloride injection 100 mL containing 13 dosage of the forementioned drugs was administrated through intravenous infusion for three times within the whole course of 5-14 d, respectively for each group. RESULTS: The clinical efficacy rates were 97 % for both piperacillin/sulbactam group and piperacillin/tazobactam group. The bacterial efficacy rates were 96 % and 100 %, together with the susceptibility rates of 98 % and 100 %, respectively for each. Adverse reaction rates were 5 % equally for both groups. CONCLUSION: The results show that piperacillin/sulbactam combination is effective and safe in the treatment of bacterial infections.

关 键 词：哌拉西林 单盲法 随机对照试验 细菌感染 药物疗法 哌拉西林-舒巴坦 哌拉西林-他唑巴坦 

分 类 号：R978.1[医药卫生—药品] R56[医药卫生—药学]