心肌钠氢交换抑制药在心血管疾病治疗中的应用  

Use of myocardial Na^+/H^+ exchanger inhibitor in treatment of cardiovascular disease

作　　者：黄震华[1] 

机构地区：[1]上海第二医科大学附属第九人民医院心血管病研究室,上海200011

出　　处：《中国新药与临床杂志》2005年第3期239-242,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：心肌钠氢交换抑制药通过抑制心肌细胞内外钠氢交换,从而防止或减少心肌细胞内钙超负荷。研究表明心肌钠氢交换抑制药对心肌缺血、再灌注损伤、心肌肥厚和心力衰竭有明确的治疗作用。Myocardial Na +/H + exchanger inhibitor may prevent or decrease myocardial intracellular calcium overload through inhibiting myocardial Na +/H + exchange. Myocardial Na +/H + exchanger inhibitor possesses obvious treating effect for myocardial ischemia, reperfusion injury, myocardial hypertrophy and heart failure. The results showed that myocardial Na +/H + exchanger inhibitor can offer benefit for the treatment of ischemia and postinfarction heart failure.

关 键 词：心血管疾病 心肌缺血 心力衰竭 充血性 钠氢交换抑制药 阿米洛利 卡立泊来德 

分 类 号：R972[医药卫生—药品] R541[医药卫生—药学]