利洛司酮实验药代动力学研究  

Pharmacokinetic Studies of Lilopristone in Rats

作　　者：朱长虹[1] 付官铭[1] 左明达[1] 庞雪冰[1] 

机构地区：[1]同济医科大学计划生育研究所

出　　处：《同济医科大学学报》1994年第1期56-58,共3页Acta Universitatis Medicinae Tongji

摘　　要：利用高效液相色谱分离测定的方法，研究了大鼠口服利洛司酮的药代动力学。回收率＞79％．检测灵敏度为0.1μm／ml，变异系数＜5％，口服利洛司酮后吸收迅速，24h内基本消除。After oral feeding of lilopristone to rats, the serum concentrations were de termined by high pressure liquid chromatography (HPLC).The mean recoveries were greater than 79%.0.1μg/ml of lilopristone could be determined satisfactorily.The coeffi cient of variation was ＜5%.When given orally,lilopristone was quickly absorbed, and al most all of it was eliminated within 24 hours.The blood concentration-time curve for liloprin stone was adequately fitted to one compartment models.

关 键 词：利洛司酮 药代动力学 高效液相色谱 

分 类 号：R979.22[医药卫生—药品]