丹参对低氧性腺泡内肺动脉构型重组的阻抑效应  

The Inhibitory Effect of Radix Salviae Miltiorrhizae on Hypoxic Structural Remodeling of Intra-acinar Pulmonary Arteries

作　　者：席思川[1] 车东媛[1] 张婉蓉[1] 

机构地区：[1]同济医科大学基础医学院病理学教研室,武汉430030

出　　处：《同济医科大学学报》1994年第2期81-83,162,共4页Acta Universitatis Medicinae Tongji

基　　金：国家八.五攻关课题

摘　　要：实验用光镜、电镜和形态计量学方法，动态地观察中药丹参对低氧大鼠腺泡内肺动脉（IA-PA）构型重组过程的影响。结果证明：丹参不仅能扩张IAPA管径，减轻低氧对内皮细胞的损伤（4d），还能阻抑IAPA肌化增强现象。提示丹参在阻抑低氧性IAPA构型重组和肺动脉压升高方面，具有十分重要作用。By use of light-and electromicroscopic and morphometric methods,we studiedthe inhibitory effect of radix salviae miltiorrhizae(RSM）on hypoxic structural remodeling ofintra-acinar pulmonary arteries（IAPA）.The results showed that,compared with H+NSgroup,RSM conld prevent endothelial cell damage of IAPA induced by hypoxia and dilatethe IAPA from the 4th day of hypoxia;after the 14th day of hypoxia.It could also inhibitthe medial hypertrophy of muscular arteries and muscularization of non-muscular arteries.Therefore,it is concluded that preserving the endothelial cells and dilating IAPA by RSMplay a key role in inhibiting structural remodeling of IAPA and pulmonary hypertension.

关 键 词：丹参 高血压 内皮细胞 肺性高血压 

分 类 号：R544.102[医药卫生—心血管疾病]