静脉输注卡托普利对狗心肌梗塞并发急性左心衰的影响  

Intravenous Captopril in Experimental Acute Heart Failure Complicated with AMI

作　　者：吴华[1] 赵华月[2] 郑信华[2] 郭志凌[2] 蔡丹[3] 

机构地区：[1]同济医科大学附属同济医院核医学科,武汉430030 [2]同济医科大学附属同济医院内科,武汉430030 [3]同济医科大学附属同济医院外科,武汉430030

出　　处：《同济医科大学学报》1994年第4期272-275,共4页Acta Universitatis Medicinae Tongji

摘　　要：建立狗急性心肌梗塞合并急性左心衰模型，静脉输注血管紧张素转换酶抑制剂卡托普利，给药后5min即引起左室舒张末压和总外周阻力显著降低，心输出量增加（P＜O.01），左室dp/dt_(max)无显著变化；给药后20min血浆血管紧张素Ⅱ浓度降低54.1％（P＜O.05），血浆6-酮-PGF_(1a)无显著性变化。结果表明静脉输注卡托普利能使急性左心衰时恶化的心功能和血流动力学获快速改善，并对激活的肾素系统产生快速抑制。Captopril was Infused intravenously in 5 dogs after establishment of acute heart failure complicated with MI.Another 5 dogs served as controls.A significant reduc-tion of left entricular end diastolic pressure and total peripheral resistance as well as an in-crease of cafdiac output were achieved 5 minutes after captopril infusion(P＜0.01）,while LV dp/dt_max did not change significantly.Plasma levels of angiotensin Ⅱ was decreased by 54.1％ after administration（P＜0.05）.The drug did not show significant effect on plasma 6-keto-PGF_1 and TXB_2.It is suggested that in acute heart failure complicated with AMI,in-travenous captopril may exert a rapid inhibition on activated renin angiotensin system and improve impaired cardiac function and hemodynamics.

关 键 词：心肌梗塞 心力衰竭 卡托普利 

分 类 号：R542.22[医药卫生—心血管疾病]