胎脑移植术治疗小脑萎缩症30例  

Homoplastic Transplantation of Fetal Cerebellar Tissue on 30 Cases of Cerebellar Atrophy.

作　　者：张均珠[1] 鲁广恩[1] 刘舫[1] 

机构地区：[1]济南铁路中心医院神经外科,济南250003

出　　处：《铁道医学》1989年第1期1-2,共2页Railway Medical Journal

摘　　要：本文报告胎脑组织移植治疗小脑萎缩症30例,近期有效率达96.7％,短期随访疗效显著者占45％,有效者占55％。本文对病因、胎脑“供体”的胎龄与疗效的关系、手术指征、手术要点等方面进行了讨论,指出手术关键技术的掌握是影响手术效果的重要因素。This paper dealt with 30 cases of cerebellar atrophy treated by homoplastic transplantation of fetal cerebellar tissue. Patient's age varied from 5～57 years old(mean age, 33.5). The duration varied from 1～10 years. The causes of disease, dominant inheritant ataxia 10, long-term drinking 9, crebellar injury 2 and unknown cause 9. Symptom: All the patients had sturred speech hacking coughs during swallowing and ataxia. Pathological changes: slight corebellar atrophy 16, moderate 9 and severe 5. The homograft, one case from fetus of 3.5 months, 28 cases from fetus of 4～7 months and 1 case from fetus of 9 months. Method: Bilateral suboccipital craniotomy was done in one case and right sided suboccipital craniotomy, in the rest 29 cases. At the same time, cellulated tissue suspension was made from the fetal cerebellar tissue from the donor and the suspenssion was transplanted into the cerebellar dentate neuclus region of the recipient. Short-term results: 11 cases (36.7％) showed evident effectiveness, 18 cases showed improvement and 1 case showed no improvement. In a short-term follow-up of 29 cases, 9 cases (45％) showed evident effectiveness, 11 cases (55％) showed improvement, The authors found that those with dominant inhertant ataxia got better results, and cerebellar tissue from an carly stage fetus was likely to survive and lead to better results, while corebellar tissue from fetus of 4～6 months was optimal for transp lantation. If the recipient was younger, the duration of disease was shorter, and the cerebellar atrophy was slighter, and the effectiveness would be better. In this paper, the authors gave their own views of the operational indieations and its key points of operation techniques.

关 键 词：胎脑移植术 小脑萎缩 

分 类 号：R651.105[医药卫生—外科学]