八例胰岛素依赖型糖尿病胰岛移植临床研究  

Transplantation of Pancreatic Islets for Treatment of Patients with Insulin-dependent Diabetes Mellitus; with a Clinical Analysis of 8 cases

作　　者：郭如意[1] 郭践诚 王兴富 张书德 李庆华 杨伟 孙文芝 

机构地区：[1]沈阳铁路局中心医院,沈阳110001

出　　处：《铁道医学》1989年第3期140-142,共3页Railway Medical Journal

摘　　要：8例胰岛素依赖型糖尿病人,每例采用经短期体外培养的8～10个胎儿胰岛组织,行腹腔内移植后,均获不同程度疗效,24小时糖尿定量平均由174.36mmol下降至80.47mmol,空腹血糖平均由15.96mmol/L降至9.18mmol/L,餐后2小时血糖平均由20.95mmol/L降至12.47mmol/L。胰岛素用量平均减少33.3～66.6％,两例暂停胰岛素治疗。血清C-肽释放值明显升高,眼底病变无变化。Pancreas islet transplantation has been performed in eight cases of insulin-dependent diabetes mellitus. The conditions of all the cases were poorly controlled, and keto-acidosis occurred repeatedly. Effect to a various extent was obtained in all the patients who received the transplantation of 8-10 foetus pancreatic tissues cultured in vitro shortly. The urine sugar for 24 hours lowered from the mean value of 174.36mmol/L down to 80.47mmol/L. Fast blood sugar lowered from 20.95mmol/L of the mean value down to 12.47mmol/L. The dosage of insulin adminastra tion decreased by one third to two third than hefore transplantation, and two patients even stopped usinginsulin therapy transiently releasing value of serum C-peptide elevated obviously(detailed data presented in table 1), There were no changes in the ocular fundi of the patients.

关 键 词：糖尿病 胰岛移植 胰岛素 

分 类 号：R587.105[医药卫生—内分泌]