利用“分层法”评价中药复杂体系药效时有关权重设立的讨论  

A Discussion Concerning Establishment of Weight in Assessing TCM Effectiveness of Complex System by Method of Stratification

作　　者：陶佳林[1] 赵玉男[1] 王笑[1] 雷帆[1] 邢东明[1] 杜力军[1] 

机构地区：[1]清华大学生物科学与技术系药物药理研究室,北京100084

出　　处：《世界科学技术-中医药现代化》2005年第1期33-37,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：清华大学基础研究基金(JC2000050):中药药代动力学方法研究

摘　　要：本文讨论了以分层法进行中药药效评价时权重设立的问题,主要由以下几部分组成: 1．建立递阶层次结构;2．构造两两比较判断矩阵;3．计算单一准则下元素的相对权重;4．计算各层元素的组合权重。由于中药作用具有多途径、多靶点的特性,因此评价过程中权重的设立就占有重要位置。它直接影响对被评价对象药效作用的评判。全面解决中药作用多途径、多靶点药效学评价的数学方法,客观量化的评价中药的综合药效,是中药现代化进程中一个值得研讨的命题。This article discusses the establishment of weight in the assessment of TCM effectiveness by the method of stratification, which is composed of the following parts: (1) the establishment of hierarchical strata structure, (2) the construction of pair wise comparison decision matrix, (3) the computation of the relative weight of elements under a single norm and (4) the computation of the combined weight of elements in all the strata. The establishment of weight plays a significant part in the assessment since the functions of traditional Chinese medicine is characterized by multi - ways and multi - targets, which is able to directly influence the judgement of the effectiveness of assessed medicaments. It is a subject worthwhile being studied in the progress of the modernization of TCM to generally settle down the mathematic method for the assessment of TCM effectiveness with multi - ways and multi - targets and to assess the comprehensive effectiveness of TCM by means of objective quantization.

关 键 词：中药药效 多途径 多靶点 设立 药效学 评价 中药现代化 权重 直接影响 准则 

分 类 号：N945.16[自然科学总论—系统科学] R285[医药卫生—中药学]