毛细管电泳法在手性药物分离中的应用  

Application of Capillary Electrophoresis to Separation of Chiral Drugs

作　　者：李伟东[1] 蔡宝昌[1] 

机构地区：[1]南京中医药大学,南京210029

出　　处：《世界科学技术-中医药现代化》2005年第1期47-51,55,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：江苏省科技厅科技攻关重大项目(BK2001209):通塞脉片复方活性部位群及其药效学研究

摘　　要：毛细管电泳是一种毛细管为分离通道、以高压直流电为驱动力、依据样品各组分之间淌度和分配行为上的差异而实现分离的高效、高选择性的色谱技术,广泛应用于农业、医药、化工等领域。该技术对手性药物分离分析具有独特的优点。本文对近年来高效毛细管电泳用于手性化合物拆分的主要分离模式进行了综述。可以预见,该技术在生命科学领域将有着越来越广泛的应用,尤其是毛细管电泳单细胞分析正在成为细胞水平药理学及了解生命过程的一种活体检测手段。Capillary electrophoresis is a chromatographic technology with high efficiency and selectivity, which carries out separation by taking capillary tubes for separation passage and high voltage electricity for motive force and in accordance with the difference of mobility and distribution behaviors of all the components of samples. It has unique merits in the separation and analysis of chiral drugs and is widely used in the areas of agriculture, medicine and chemical engineering. This article summarizes the application of capillary electrophoresis to the main modes of separation of chiral compounds in the last years. It can be foreseen that this technology will be applied more and more widely in the area of life science, and the analysis of monocells by capillary electrophoresis in particular is becoming a means of in vivo detection in pharmacology at the cellular level and in understanding the process of life.

关 键 词：手性药物 毛细管电泳法 分离分析 色谱技术 药理学 高效毛细管电泳 行为 农业 分配 驱动力 

分 类 号：N09[自然科学总论—科学技术哲学] R284[医药卫生—中药学]