建立中药复方用半仿生提取研究的技术平台  

Establishment of A Platform for Study of Compound Dncgs of Chinese Medicine by Method of Semi - bionic Extraction

作　　者：张兆旺[1] 孙秀梅[1] 

机构地区：[1]山东中医药大学,济南250014

出　　处：《世界科学技术-中医药现代化》2005年第1期56-59,66,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：教育部科学技术研究重点项目(地方:03075):方剂药效物质提取新技术"半仿生提取模式"的研究;国家自然科学基金资助项目(30472193):中药复方药效物质用"半仿生提取"的方法研究

摘　　要：半仿生提取法(SBE法)是针对中药药效物质提取中存在的“唯成分论”和“通则论”,采用“灰思维方式”将整体药物研究法与分子药物研究法相结合,从生物药剂学的角度为经消化道给药的中药制剂创立的一种提取新技术。经对多种中药及其复方的研究,结果皆提示:半仿生提取法有可能替代(WE法水提取法);(SBAE法半仿生提取醇沉淀法)有可能替代(WAE法水提醇沉淀法)。本文以黄连解毒汤和慈航丹为例,对建立中药复方半仿生提取研究的技术平台作了介绍。The method of semi - bionic extraction (SBE) is a new technology of extraction, which is created, by the way of ' gray thinking' to combine the method of study on the wholism of drugs with the method of study on the molecules of drugs and in view of existing ' the theory of unique importance of medicinal components' and ' the theory of general rules', especially for the preparations of Chinese medicine teken through digestive tract as considered from the viewpoint of bio - pharmaceutics. The result of study on quite a lot of Chinese drugs and their compounds shows that the SBE method may replace the method of water extraction (WE) and the method of semi - bionic alcohol extraction (SBAE) may replace the method of water alcohol extraction (WAE). Taking Huangliangjiedutang (Panax Notoginseng Detoxicating Liquid) and Cihangdan Pill for examples, this article describes the establishment of the technical platform for the study of the semi - bionic extraction of the compounds of Chinese drugs.

关 键 词：中药复方 半仿生提取法 消化道给药 中药药效 黄连解毒汤 药物研究 醇沉 替代 沉淀法 成分 

分 类 号：R285[医药卫生—中药学] R283[医药卫生—中医学]