头孢克洛降解产物的电化学行为和测定  

Electrochemical behavior of the degradation product of cefaclor and its application to analytical chemistry

作　　者：严金龙[1] 

机构地区：[1]盐城工学院化学工程系,盐城224003

出　　处：《分析试验室》2005年第2期59-61,共3页Chinese Journal of Analysis Laboratory

基　　金：江苏省教育厅自然科学科研课题(03KJD150277);盐城工学院优秀青年重点项目(YQ2001003)

摘　　要：研究了在0.5mol/LNaOH溶液中,头孢克洛碱性降解产物在汞膜电极上的电化学为,并依此建立了头孢克洛的微分脉冲伏安测定法。头孢克洛碱性降解产物于～-0.85V(vs.Ag/AgCl)处出一灵敏的阴极还原峰,用循环伏安法、线性扫描极谱法、微分脉冲伏安法等手段研究了其电化学行为和机理。实验表明:头孢克洛降解产物在汞膜电极上具有明显的吸附性,电化学反应的电子转移数为2。伏安峰高与头孢克洛的浓度在1.0×10-8～5.0×10-6mol/L范围内有良好的线性关系。方法的检出限为5.0×10-9mol/L,方法可用于药品欣可诺颗粒剂中头孢克洛的测定。In the medium of 0.5 mol/L NaOH solution. A sensitive peak of cefaclor (CFC) at about -0.85 V (vs. Ag/AgCl) at mercury film electrode by differential pulse voltammetry was found. The electrochemical behavior and reaction mechanism of this system have been studied by linear sweep polarography, cyclic voltammetry and pulse polarography. The experiments indicated that the number of electron involved in the electro-reduction was 2, and there was a good linear relationship between the peak current and the concentration of CFC in the range of 1.0×10^(-8)～5.0×10^(-6) mol/L. The detection limit of the method is 5.0×10^(-9) mol/L. The concentration of CFC in Xinkenuo has been determined with good results by this method.

关 键 词：头孢克洛 微分脉冲伏安法 电化学行为 测定 

分 类 号：O657.1[理学—分析化学]