氮-氧偶极化合物在不对称催化反应研究中的应用  

Application of N-Oxides in Asymmetric Catalytic Reactions

作　　者：申永存[1] 李燕霞[2] 闻雪敬[2] 冯小明[3] 

机构地区：[1]武汉理工大学化工学院,武汉430070 [2]湖北省新型反应器与绿色化学工艺重点实验室,武汉430074 [3]四川大学化学学院,成都610064

出　　处：《有机化学》2005年第3期272-281,共10页Chinese Journal of Organic Chemistry

基　　金：湖北省教育厅优秀中青年教师基金(No.2002B20001)资助项目.

摘　　要：氮-氧偶极化合物中的氮-氧偶极具有较强的极性,表现出良好的亲电、亲核性能,可与许多物质形成分子加成产物,也可与许多金属离子和可提供空轨道的非金属原子形成配合物和发生配位作用.近年来已发现,手性和非手性的氮-氧偶极化合物可用于一些不对称催化反应中,着重讨论这方面的进展状况.N-O moiety of N-oxide has high polarity and shows excellent nucleophilicity and electrophilicity. It can form addition products with many substances, complex and coordinate with many metal ions and non-metal atoms with empty orbital. More recently, chiral and achiral N-oxides have been found to catalyze some asymmetric reactions, such as Sakurai-Hosomi, Aldol, Strecker ones as well as ring opening of epoxides and cyanosilylation of ketones. The paper was focused on the development of application of N-oxides in asymmetric catalytic reactions.

关 键 词：氮-氧偶极化合物 不对称催化反应 手性 非手性 

分 类 号：O643.3[理学—物理化学]