LONG-RANGE CORRELATIONS IN DNA SEQUENCES USING TWO-DIMENSIONAL DNA WALKS  

作　　者：JinChena Lin-xiZhanga De-luZhaob 

机构地区：[1]DepartmentofPhysics,WenzhouNormalCollege,Wenzhou,325027,China [2]PolymerPhysicsLaboratory,CenterofMolecularScience,InstituteofChemistry,ChineseAcademyofSciences,Beijing100080,China

出　　处：《Chinese Journal of Polymer Science》2005年第1期11-16,共6页高分子科学（英文版）

基　　金：This work was financially support by the National Natural Science Foundation of China(Nos.29874012,20174036,20274040);Natural Science Foundation of Zhejiang Province(No.10102).

摘　　要：The characterization of long-range correlations and fractal properties of DNA sequences has proved to be adifficult though rewarding task mainly due to the mosaic character of DNA consisting of many patches of various lengthswith different nucleotide constitutions.In this paper we investigate statistical correlations among different positions in DNAsequences using the two-dimensional DNA walk.The root-mean-square fluctuation F(l)is described by a power law.Theautocorrelation function C(l),which is used to measure the linear dependence and periodicity,exists a power law ofC(l)-l^(-μ).We also calculate the mean-square distance<R^2(l)>along the DNA chain,and it may be expressed as<R^2(l)>-l^(?)with 2>γ>1.Our investigations can provide some insights into long-range correlations in DNA sequences.The characterization of long-range correlations and fractal properties of DNA sequences has proved to be adifficult though rewarding task mainly due to the mosaic character of DNA consisting of many patches of various lengthswith different nucleotide constitutions.In this paper we investigate statistical correlations among different positions in DNAsequences using the two-dimensional DNA walk.The root-mean-square fluctuation F(l)is described by a power law.Theautocorrelation function C(l),which is used to measure the linear dependence and periodicity,exists a power law ofC(l)-l^(-μ).We also calculate the mean-square distance<R^2(l)>along the DNA chain,and it may be expressed as<R^2(l)>-l^(?)with 2>γ>1.Our investigations can provide some insights into long-range correlations in DNA sequences.

关 键 词：Autocorrelation function DNA sequence Long-range correlation. 

分 类 号：Q523[生物学—生物化学]