川崎病患儿CD_(62p)、CD_(63)与血管内皮功能变化的临床意义  

Clinical significance of CD_(62p_,CD_(63) and vascular endothelial function in the children with Kawasaki Disease

作　　者：李香梅[1] 陈铭珍[2] 许逢明[2] 黄宇戈[2] 

机构地区：[1]珠海市疾病预防控制中心预防体检科,广东珠海519000 [2]广东医学院附属医院儿科,广东湛江524000

出　　处：《实用医药杂志》2005年第2期97-98,101,共3页Practical Journal of Medicine & Pharmacy

摘　　要：目的研究川崎病(KD)患儿CD62p、CD63与血管内皮功能变化的临床意义。方法KD患儿40例,正常对照组小儿40例。用流式细胞仪检验血小板膜糖蛋白CD62p、CD63的表达,同时用超声诊断仪测定肱动脉直径(试验前为D0,试验后为D1),计算肱动脉内径舒缩百分率(D%)。结果KD患儿治疗前后其CD62p、CD63的表达均明显高于对照组(P均<0.01);而治疗前后比较无显著性差异(P>0.05)。KD患儿治疗前后D%均明显低于对照组(P<0.01,P<0.05),而治疗后D1、D%值与治疗前的比较均无显著性差异(P>0.05)。结论KD患儿在恢复期血小板活化程度仍明显增高,仍有血管内皮功能障碍。如何有效地降低KD患儿血小板活性及改善血管内皮功能值得进一步研究。Objective To study the clinical significance of CD62p,CD63 and vascular endothelial function in the children with Kawasaki Disease(KD). Methods There were 40 KD patients, and 40 heath children were taken as control group. The expression of platelet membrane- glycoprotein CD62p,CD63 was measured by flow cytometry. At the sametime, the diameter of superficial brachial arteries was measured with high-resolution ultrasound, D0 as the diameter before superficial brachial arteries congested, D1 as the diameter after congested, and D%=(D1-D0)/D0×100%. Results The expression of CD62p,CD63 in KD before or after therapy were higher than that in control group(P<0.01); There were no significant difference of the expression of CD62p,CD63 between before and after therapy. D1,D% were significant higher before therapy than that of after therapy, and there were no significant difference in D1,D% between after and before therapy. Conclusion Platelets are still highly activated and there is endothelial-dependent vasodilation dysfunction in convalescent KD patients.It is need how decrease platelet-activity, and improve vascular endothelial function.[

关 键 词：血管内皮功能 血小板膜糖蛋白 川崎病 儿童 

分 类 号：R543.56[医药卫生—心血管疾病]