胰岛素预处理抗心律失常作用的实验研究  

Experimental study on antiarrhythmia effect of insulin on preconditioning

作　　者：张宁滨[1] 赵瑛[1] 许飒飒[1] 金成[1] 周游[1] 

机构地区：[1]哈尔滨商业大学药学院,黑龙江哈尔滨150076

出　　处：《哈尔滨商业大学学报（自然科学版）》2005年第1期17-18,共2页Journal of Harbin University of Commerce：Natural Sciences Edition

摘　　要：研究胰岛素对心肌缺血再灌注大鼠心律失常的影响.选择SD雄性大鼠,随机分成对照组(CTRL组),预适应组(IPC组),缺血/再灌注组(I/R组)卡托普利组(CPT)及胰岛素高剂量组(INSH)、胰岛素低剂量组(INSL),采用改良推管法建立大鼠在体心肌缺血再灌注模型,以心律失常发生率为指标,观察胰岛素的心肌预适应保护性作用.结果表明,胰岛素可以显著降低缺血及再灌时室性早搏的发生;降低缺血时室颤、室速的发生率.胰岛素对缺血再灌注心肌具有预适应样抗心律失常作用.To study the effect of insulin in ventricular arrhythmia . The SD rats are randomly allocated into six groups: Ctrl, IR, IPC, CPT, INSH, INSL group. An improved method of pushing tube to occlude the coronary artery is applied to the ischemic reperfusion models of rats. This paper observes the protective function of insulin by measuring incidence of ventricular arrhythmia. Insulin can reduce incidence of ventricular premature during ischemia and reperfusion; reduce incidence of ventricular tachycardia ,ventricular fibrillation.The results showed that insulin have anti-arrhythmia effect of preconditioning on ischemic reperfusion cardiac muscle.

关 键 词：胰岛素 抗心律失常作用 预适应 心肌缺血再灌注 发生率 大鼠 实验研究 注模 降低 SD 

分 类 号：N945.17[自然科学总论—系统科学] R587[医药卫生—内分泌]