β_3肾上腺素能受体与心血管疾病  

β_3-Adrenergic Receptor and Cardiovascular Diseases

作　　者：魏晓萍[1] 陈雅慧[1] 惠起源[1] 

机构地区：[1]延安大学医学院生理教研室,陕西延安716000

出　　处：《心血管病学进展》2005年第2期204-206,共3页Advances in Cardiovascular Diseases

摘　　要：β3 肾上腺素能受体是新近发现的,继β1 和β2 之后的第 3个β型肾上腺素能受体亚型。近年来国内外的研究表明:该受体基因突变或基因多态性与机体肥胖及心血管疾病相关;心力衰竭时该受体的含量明显增加,应用该受体激动剂后可明显加重心力衰竭,增加病死率。β3 肾上腺素能受体与心血管疾病的相关研究可能为心血管疾病的预测、防治开发一种新思路。β_3-adrenergic receptor is a newly found β- adrenergic receptor subtype,following β_1 and β_2.Latest studies from home and abroad indicate that gene mutation and gene polymorphism of this receptor are related to obesity and cardiovascular diseases.The receptor number is increased during heart failure and using agonist of this receptor may aggravate heart failure and increase mortality.The discovery that β_3-adrenergic receptor is related to cardiovascular diseases may open up a new thinking for the prognosis,prevention and treatment of cardiovascular diseases.

关 键 词：Β3肾上腺素能受体 心血管疾病 心力衰竭 受体激动剂 亚型 病死率 肥胖 发现 受体基因 机体 

分 类 号：R54[医药卫生—心血管疾病]