铅对中枢神经系统功能及母体铅负荷对子代中枢神经系统发育的影响  

Effects of prenatal exposure lead on the function of central nervous system of newborn monkeys

作　　者：梁华[1] 闭中强[1] 樊建康[1] 陈晓琴[1] 杨洁芳[1] 

机构地区：[1]广西职业病防治研究所

出　　处：《卫生毒理学杂志》1994年第1期7-9,共3页Journal of Health Toxicology

摘　　要：采用猕猴作为实验对象进行了铅对中枢神经系统功能以及母体铅负荷对于代中枢神经系统发育的影响的实验研究。实验发现染铅组母猴脑铅和脑组织脂质过氧化物含量明显高于对照组（Ｐ＜０．０５），中枢神经递质５－ＨＴ含量降低。仔猴的观察指标改变与母猴相似。结果提示接触５～１５ｍｇ／ｋｇ剂量的醋酸铅可导致中枢神经细胞膜和功能的损害，并可发生中枢神经系统功能的改变。母体铅可经胎盘和乳汁传递至子代，长期铅接触可致子代脑发育不良。The effects of prenatal exposure to lead acetate on the function of central nervous system of newborn Rhesus monkeys were studied. In the exposed groups, the contents of lead and lipid peroxide in brain were higher (p<0. 05) ,and the contents of the serotonin(5-HT) in cerebellum were lower than that of controls. The changes in the filial generation were similar to their mothers. These results suggested that at the doses of 5￣15mg/kg body weight,lead could result in both structural and functional damages in the cellular membranes of the central nervous system in monkeys.It is suggested that the mother's lead could be transferred to the filial generation during pregnency and lactation.

关 键 词：醋酸铅 中枢神经系统 神经递质 

分 类 号：R135.11[医药卫生—劳动卫生]