镉致大鼠肾损害时尿酶变化及其意义  

Increase of urinary enzymes in rats following a singe subcutaneous administration of cadmium

作　　者：黄厚今[1] 金泰[1] 董国宾[1] 赵跃[1] 华浩根[1] 

机构地区：[1]遵义医学院预防医学教研室

出　　处：《卫生毒理学杂志》1994年第2期92-94,共3页Journal of Health Toxicology

摘　　要：我们报道镉中毒大鼠尿液主要生化指标和肾皮质组织病理改变，结果表明，尿总蛋白、葡萄糖、ｒ－谷氨酰转移酶（ｒ－ＧＴ）、碱性磷酸酶（ＡＬＰ）和Ｎ－乙酰－Ｄ－氨基葡萄糖苷酶（ＮＡＧ）排泄均明显增加，光镜和电镜下见近曲小管细胞浊肿、水样变性，微绒毛稀疏脱落，线粒体肿胀变性及胞浆空泡形成。提示Ｃａ２＋是ＣｄＭＴ的毒作用形式，尿ｒ－ＧＴ、ＮＡＧ是镉性肾损害的理想监测指标。In order to investigate the changes in urinary biochemical indicators and histopathology of renal cortex an acute renal damage was induced by a single subcutaneous administ ration of cadmiummetallothionein(CdMT)to male Wistar rats used as a model for cadmium poisoning.The results showed that urinary total protein .glucose, rGT,ALP and NAG significantly,increased while with the help of light and electron microscopy, the morphologic changes in treated rats were found as cloudy swelling,hydropic degeneration.rarefration and exfoliation of microvilli.mitochondrial alterations and widespread vesiculation of proximal tubular cells.It suggested that cadmium(Cd2+).Is the toxic form of CdMT,and both r-GT and NAG may be the better biomarkers of cadmium nephrotoxicity.

关 键 词：镉金属硫蛋白 尿酶 肾病理学 大鼠 

分 类 号：R992[医药卫生—毒理学]