血清催乳素与新生儿惊厥关系的研究  

Relationship between serum prolactin level and neonatal seizures

作　　者：杜彩霞[1] 赵凤临[1] 叶鸿瑁[1] 魏玲[1] 

机构地区：[1]北京大学第三医院儿科,100083

出　　处：《中华围产医学杂志》2005年第1期27-30,共4页Chinese Journal of Perinatal Medicine

摘　　要：目的　探讨血清催乳素 (PRL)与新生儿惊厥发作之间的关系 ,评价发作后血清PRL含量升高作为新生儿惊厥诊断指标的临床意义。　方法　 3 5例急性脑病新生儿以有无临床典型惊厥发作和 (或 )脑电图出现放电活动分为惊厥组 17例、无惊厥组 18例 ,对照组 17例。化学发光方法检测发作后 15～ 3 0min(第 1时间点 )、2h(第 2时间点 )及发作停止后 2～ 4d(第 3时间点 )的血清PRL含量。　结果　 (1)惊厥组第 1时间点的血清PRL含量明显高于第 2及第 3时间点 ,且高于无惊厥组及对照组的相应时间点。(2 )第 1时间点PRL绝对值≥ 170 μg/L的敏感度为 94.1% ,特异度为 88.9% ;第 1与第 2时间点PRL之比≥ 1.5 ,其敏感度为 88.2 % ,特异度为 88.9%。　结论　 (1)PRL与新生儿惊厥关系密切。 (2 )惊厥发作后 15～ 3 0min(峰值 )血清PRL绝对值及发作后 15～ 3 0min(峰值 )与 2h(基线值 )的PRL之比升高对临床诊断新生儿惊厥有一定的参考意义。Objective To investigate the relationship between serum prolactin(PRL) level and neonatal seizures and to evaluate the clinical significance of PRL as a neonatal seizures marker to diagnose neonatal seizures. Methods Thirty five newborn infants with acute encephalopathy were divided into two groups: the ictal group included infants with typical clinical symptom and/or electrographic seizures and the nonictal group are those without electrographic seizures or clinical behaviors. The control group included 17 newborns. Serum PRL levels were determinded by immulite assay system at 15～30 min postictally; 2 h postictally and 2～4 days after the end of seizures. Results In the ictal group, serum PRL levels were significantly higher at 15～30 min[(302.6±93.5) μg/L] than that of 2 h [(128.1±71.4) μg/L], nonictal[(101.2±31.4)μg/L and (89.9±36.2) μg/L] and control group[(73.3±20.7) μg/L and (68.6±29.5)μg/L], P<0.05 . Serum PRL levels≥170 μg/L had a sensitivity of 94.1% and specificity of 88.9% at 15～30 min, while the ratio of PRL level at 15～30 min over 2 h ≥1.5 had a sensitivity of 88.2% and specificity of 88.9%. Conclusions PRL level is closely related to neonatal seizures.Serum PRL level over ≥170 μg/L at 15～30 mins postictally and elevated PRL ratio over 1.5 (level of 15～30 min over 2 h postically) have clinical significance in diagnosing neonatal seizures.

关 键 词：PRL 新生儿惊厥 血清 发作后 催乳素 特异度 惊厥发作 时间点 绝对值 结论 

分 类 号：R722.1[医药卫生—儿科]