影响脐血促红细胞生成素水平的多因素分析  

Multi-analysis of factors affecting erythropoietin level of umbilical blood

作　　者：涂绘玲[1] 叶鸿瑁[1] 李诗兰[2] 

机构地区：[1]北京大学第三医院儿科,100083 [2]北京大学第三医院妇产科,100083

出　　处：《中华围产医学杂志》2005年第1期34-37,共4页Chinese Journal of Perinatal Medicine

摘　　要：目的　研究不同孕期脐血促红细胞生成素 (EPO)水平 ,并分析其影响因素。　方法　收集不同孕期脐血共 10 6例 ,分为四组 :正常足月儿组 (足月儿组 )、母患高血压组 (高血压组 )、母患糖尿病组 (糖尿病组 )、宫内窘迫或生后窒息组 (窒息组 )。用放射免疫法测定其EPO水平 ,并分析EPO与胎龄、分娩方式、不同妊娠合并症的关系。以EPO为因变量 ,以新生儿胎龄、性别、分娩方式、母患高血压、母患糖尿病、宫内窘迫或生后窒息为自变量 ,进行多元线性逐步回归。　结果　母患高血压、母患糖尿病、宫内窘迫或生后窒息是影响脐血EPO水平的重要因素 (P均 <0 .0 1) ,胎龄、性别、分娩方式均为非重要的影响因素。分析四组EPO水平 ,结果显示 :足月儿组脐血EPO值为 (1.0 73± 0 .495 ) μg/L ,高血压组、糖尿病组、窒息组脐血EPO值分别为 (1.994± 1.467)、(2 .0 87± 1.14 6)、(1.93 8± 1.5 0 4) μg/L ,与足月儿组比较差异均有显著性 (P均 <0 .0 5 )。　结论　缺氧是影响EPO水平的一个重要因素 ,脐血EPO水平可作为胎儿急、慢性缺氧的一个指标。Objective To study the level of umbilical plasma erythropoietin (EPO) in normal and abnormal pregnancy and analyze the influence factors of EPO. Methods EPO concentration in 106 umbilical plasma were measured by enzyme immonoassay. Samples were divided into four groups: control group with healthy full term newborns; hypertension group with neonates born to mothers with hypertension; diabetiec group with neonates born to mothers with diabetes; asphyxia group with neonates with fetal distress or asphyxia. The relationship between the concentration of EPO and gestational age, mode of delivery and pregnant complications were analysed. Results Mothers with hypertension, diabetes, fetal distress or neonatal asphyxia were important factors influencing umbilical blood EPO production ( P <0.01), whereas the gestation age, sex, mode of delivery were not. The EPO level in hypertensive, diabetic, asphyxia group(1.994±1.467, 2.087±1.146 and 1.938± 1.504) μg/L was higher than that of the control group (1.073±0.495) μg/L ( P <0.05). Conclusion Hypoxia is an important factor of increasing synthesis of EPO. EPO can be an indicator of neonatal acute and chronic hypoxia.

关 键 词：促红细胞生成素(EPO) 脐血 糖尿病 高血压 窒息 胎龄 宫内窘迫 水平 重要因素 自变量 

分 类 号：R714.7[医药卫生—妇产科学]