重症SARS患者应用甲基强的松龙注射剂时机对疗效和不良反应影响  

Effect and ADRs of Metrisone Administration Occasion Dosage to Critical Patients with Severe Acute Respiratory Syndrome

作　　者：王瑾[1] 王昆[1] 陈 徐艳萍[1] 周践[1] 周筱青[1] 王睿[1] 

机构地区：[1]中国人民解放军总医院,北京100853

出　　处：《解放军药学学报》2005年第1期67-70,共4页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：国家 8 63高技术研究发展计划资助项目 ;No .2 0 0 3AA2 0 810 7

摘　　要：目的　研究甲基强的松龙注射剂的应用时机 ,对重症SARS患者疗效和不良反应的影响。方法　回顾性分析北京市小汤山医院临床确诊的 37例使用甲基强的松龙注射剂重症SARS患者的病情、用药纪录及药品不良反应发生情况 ,根据用药时机分为 3组 ,描述性分析各组病例基本病情、疗效和不良反应。结果　用药时机 >19d组的治愈率高于其他 2组 ,同时死亡率低于其他 2组 ;用药时机 0～ 9d组药物不良反应发生率为 35 .8% ,大于其他 2组 ,出院血糖高于入院血糖。结论　在重症SARS患者的治疗中 ,甲基强的松龙注射剂有着确切的疗效 ,掌握好应用时机对于重症SARS患者的治疗至关重要。Aim To study the effect and ADRs of metrisone administration occasion to critical patients of severe acute respiratory syndrome SARS.Methods The information of 37 critical patients with SARS who have been cured by metrisone in Xiaotangshan Hospital of PLA was collected by HIS system and effect and ADRs of metrisone were satiated.37 patients were divided into three groups on the basis of metrisone administration occasion.Results Cure rate of administration occasion >19 day group was higher than other groups while death rate was lower.ADRs ratio of 0～9 group was 35.8%.>19 day group occurred hyperglycemia.Conclusion Metrisone was effective to critical patients with SARS.The administration occasion of metrison to critical SRAS patient should be more cautious to balance the effect and ADRs of metrisone.

关 键 词：重症SARS 患者 甲基强的松龙 注射剂 不良反应 疗效 用药时机 发生情况 治疗 确诊 

分 类 号：R563.1[医药卫生—呼吸系统] R197[医药卫生—内科学]