杀鼠迷的毒性和致突变性研究  

Study on toxicity and mutation of racumin

作　　者：孟慧林[1] 高青[1] 黄明芳[1] 李忠生[1] 谢大英[1] 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所

出　　处：《卫生研究》1994年第2期68-70,共3页Journal of Hygiene Research

摘　　要：杀鼠迷的ＬＤ５０值分别为：大鼠３．１６ｍｇ／ｋｇ（经口）和２．７０ｍｇ／ｋｇ（经皮）；小鼠２６９ｍｇ／ｋｇ（经口，概率单位法）、２３７．０ｍｇ／ｋｇ（经口，霍恩氏法）和６．８１ｍｇ／ｋｇ（经皮）。蓄积系数为０．４。以上结果表明杀鼠迷为高毒性和高蓄积的化学物质，并容易通过皮肤吸收。杀鼠迷的Ａｍｅｓ试验，小鼠骨髓细胞微核试验和精子畸变试验均为阴性。The values of LD50 were 3.16 mg/kg (peroral) and 2.70 mg/kg (percutaneous) for rats,269.15 mg/kg (oral,probit method),237.0mg/kg (peroral,Horns method),6.81mg/kg (percutaneous) for mice respectively. The accumulative coefficient was 0.4.The above results showed that Racumin was a high toxicity and high accumulative chemicals. Racumin was absorbed by skin easily. Ames test,marrow micronucle test in mice and Sperm Malformation test of mice were negative.

关 键 词：杀鼠迷 精子畸变试验 AMES试验 

分 类 号：R992[医药卫生—毒理学]