羟自由基（OH·）对人胚肺成纤维细胞的体外作用  

Effect of exogenous hydroxyl radicals on human embryo-lung fibroblasts in vitro

作　　者：张尚明[1] 罗玲[1] 郭平[1] 户万秘[1] 王秋菊[1] 曹兆丰[1] 

机构地区：[1]华北煤炭医学院免疫病理研究室

出　　处：《卫生研究》1994年第4期204-206,共3页Journal of Hygiene Research

摘　　要：观察了由Ｆｅｎｔｏｎ反应产生的羟自由基（ＯＨ·）对人胚肺成纤维细胞的体外作用。结果表明，ＯＨ·能明显促进成纤维细胞增殖和胶原合成。由此推测，ＯＨ·可能对矽肺的发生起到一定作用。这个结论为矽肺的抗氧化防治提供了进一步理论依据。The result indicated that hydroxyl radicals could enhance uptake of 3H-TdR and 3 H-Proline, proliferation and collagen synthesis of cultured HELF. Therefore, hydroxyl radicals may play a role in silicosis. The results indicate the possibility of prevention and therapy of silicosis by antioxidant and also help us to understand other fibrosis diseases.

关 键 词：羟自由基 石英 矽肺 过氧化脂质 

分 类 号：R598.2[医药卫生—内科学]