矽宁对肺泡巨噬细胞功能的影响  

Effects of xinin on alveolar macrophages

作　　者：程玉海[1] 李雅洁[1] 马国雄 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所

出　　处：《卫生研究》1994年第4期197-200,共4页Journal of Hygiene Research

摘　　要：矽宁、梯络龙等药物具有明显降低由Ｚｙｍｏｓａｎ刺激的大鼠肺泡巨噬细胞的耗氧量，抑制其释放超氧离子、过氧化氢及化学发光量。矽宁具有较强的亲合肺巨噬细胞的能力，并有剂量－效应关系。It has been reported that some tilorone analogs can inhibit silicotic fibrosis in rats. Xinin, a new antisilicotic drug among these analogs, possesses good antifibrotic potency. The object of the present study was to determine the effects of four tilorone analogs (such as Xinin, Tilorone, 1331 and 1330) on rat alveolar macrophages (AM) in vitro. These drugs (40 μmol/L) reacted with AM in 30 min did not affect cell viability. The results showed that Xinin significantly inhibited zymosan-induced activation of the respiratory burst. It is in vitro a potent inhibitor of zymosan-stimulated oxysen consumption, superoxide anion release, hydrogen peroxide and chemiluminescence production by AM. In addition, binding of Xinin to AM was time and dose dependent. The sequence for bindining affinity was Xinin>Tilorone>1331>1330. The ability of these drugs to modify AM function in vitro correlated with their antifibrotic potency in vivo.

关 键 词：肺泡巨噬细胞 矽宁 

分 类 号：R979.3[医药卫生—药品]